Scientific Literature

Regenerative medicine with stem cells has been validated by scientific studies that support its effectiveness across a variety of clinical conditions. Below, we present how medical research supports the use of stem cells in the treatment of different conditions.

Gangrene

Medical studies have shown that stem cells can restore blood flow and promote ulcer healing in patients with gangrene. Vascular regeneration is a key outcome in the treatment of this condition, significantly improving patient health and reducing the risk of amputation. (https://doi.org/10.1186/s13287-024-03924-9).

Liver Cirrhosis

Scientific research has shown that stem cell treatment improves survival rates and liver function in patients with cirrhosis. Stem cell treatments have been shown to reduce biomarkers related to liver damage, suggesting an important advance in the treatment of chronic liver disease.(https://doi.org/10.1007/s12072-021-10199-2).

Frailty Associated with Aging

Numerous clinical studies support the use of stem cells in the treatment of age-related frailty. Stem cell application improves physical health and quality of life in patients, reducing inflammatory markers and increasing physical performance in older adults.(https://doi.org/10.1186/s13287-024-03707-2,https://doi.org/10.1186/s13287-024-03707-2).

Type 2 Diabetes

Medical literature supports the use of stem cells in the treatment of type 2 diabetes, showing that they can improve glucose control, reduce insulin dependence, and improve pancreatic beta-cell function. These advances offer new possibilities in disease management.(https://doi.org/10.12998/wjcc.v11.i21.5083, https://doi.org/10.1093/stcltm/szad060, https://doi.org/10.1186/s13287-022-02848-6).

Diabetic Foot Ulcers and Peripheral Arterial Disease

Scientific evidence has shown that stem cells are effective in the treatment of diabetic ulcers and in improving blood circulation in patients with peripheral arterial disease. These treatments have shown a high ulcer-closure rate, with long-term benefits in tissue regeneration.(https://doi.org/10.1186/s13287-022-03143-0).

Androgenetic Alopecia

In hair regeneration studies, stem cells have demonstrated effectiveness in the treatment of androgenetic alopecia, improving hair density in affected areas. Results indicate that stem cells may be a viable therapeutic option for combating hair loss without adverse effects.(https://doi.org/10.12998/wjcc.v9.i15.3741}).

Psoriasis

Scientific research has supported the application of stem cells in the treatment of psoriasis, showing significant improvement in the severity of skin lesions. After treatment, many patients have experienced lasting remission of symptoms, with a notable improvement in skin health.(https://doi.org/10.12998/wjcc.v9.i23.6798).

Post-Cesarean Scars

The application of stem cells in cesarean scars has shown significant improvements in the appearance of the skin. Results show improvement in scar area, volume, and pigmentation, without adverse effects. These findings are consistent with studies suggesting that stem cells may contribute to dermal tissue regeneration, promoting healing without additional complications. (https://doi.org/10.1186/s13287-020-01695-7).

Pulmonary Diseases

The use of stem cells in pulmonary diseases has been shown to reduce lung involvement, as seen in CT imaging studies where pulmonary damage decreased in treated patients. In addition, a decrease in inflammatory markers such as IL-6 and TNF-α has been observed, suggesting that stem cells may play an important role in controlling inflammation in the lungs and improving respiratory function.(https://doi.org/10.1186/s13287-020-01725-4).

Heart Failure

In studies on heart failure, patients treated with stem cells showed improvements in left ventricular ejection fraction compared with placebo. These results reinforce the evidence that stem cells may improve cardiovascular function and offer a therapeutic option for patients with heart failure, promoting regeneration of damaged cardiac tissue and improving ventricular function.(https://doi.org/10.1161/circresaha.117.310712).

Ankylosing Spondylitis

Stem cell treatment has shown promise in improving joint function and reducing inflammation in patients with ankylosing spondylitis. The reduction in symptoms, as well as lower levels of C-reactive protein and erythrocyte sedimentation rate, suggests that stem cells may help control the chronic inflammation that characterizes this autoimmune disease, improving mobility and quality of life.(https://doi.org/10.3892/etm.2017.4687).

COVID-19 Sequelae

Studies have shown that stem cell treatment reduced the incidence of adverse effects compared with the placebo group. In addition, a significant reduction in inflammatory cytokines, especially IL-6, was observed, highlighting the potential of stem cells to regulate the immune response and mitigate the effects of inflammation in severe infections such as COVID-19, which may accelerate recovery and reduce long-term lung damage. (https://doi.org/10.1002/sctm.20-0472).

Rheumatoid Arthritis

The application of stem cells in patients with rheumatoid arthritis has shown a decrease in joint inflammation, along with improved results in C-reactive protein (CRP) and erythrocyte sedimentation rate tests. In addition, the therapeutic effects of stem cells may be maintained for years, providing long-term relief from inflammation and joint pain. This regenerative approach is supported by medical literature suggesting that stem cells may promote cartilage repair and prevent progressive joint damage. (https://doi.org/10.2147/dddt.s225613).

Progressive Multiple Sclerosis

Studies of progressive multiple sclerosis have shown that stem cell treatment may improve disability scores in patients, reflecting a reduction in neurological symptoms and an improvement in quality of life. Over more than 11 years of follow-up, no serious adverse side effects were reported, supporting the safety and efficacy of stem cells as a viable therapeutic option for neurodegenerative disorders.(https://doi.org/10.1016/j.clineuro.2022.107475).

Type 1 Diabetes

Stem cell treatment in patients with type 1 diabetes has shown positive results in clinical remission of the disease, with increased C-peptide levels, indicating improved pancreatic function. This treatment has the potential to ease insulin dependence and improve glycemic control, and scientific literature supports it as an emerging strategy to treat autoimmune diabetes and restore pancreatic function. (https://doi.org/10.1186/s13287-021-02417-3).

Facial Paralysis (Bell’s Palsy)

The use of stem cells to treat facial paralysis, such as Bell’s palsy, has shown encouraging results, with progressive improvements in facial function. Patients treated with stem cells experienced significant recovery in their ability to close the eye and in facial muscle function, as evidenced at 28 months of treatment, supporting the efficacy of stem cells in regenerating nerves and tissues affected by this type of facial paralysis.(https://doi.org/10.12998/wjcc.v11.i12.2817).

Systemic Lupus Erythematosus

In patients with systemic lupus erythematosus (SLE), stem cell treatment has shown significant improvement in symptoms, with a decrease in SLEDAI scores, which evaluate the signs and symptoms of the disease. In addition, improvement was observed in inflammation-related biomarkers such as TGF-β, reinforcing the therapeutic role of stem cells in the treatment of complex and chronic autoimmune diseases such as SLE.(https://pubmed.ncbi.nlm.nih.gov/35820718/).

Septicemia

Stem cells showed positive effects in septicemia by modulating inflammation. An initial increase in inflammation was observed, followed by a decrease, with changes in biomarkers such as IL-8, IL-10, and TGF-β. Although coagulation was activated, no thromboembolic events occurred, demonstrating safety in their use.(https://doi.org/10.1002/stem.2891).

Crohn’s Disease

In patients with Crohn’s disease, stem cell infusions significantly reduced disease activity indices and steroid use. Side effects were mild, highlighting their efficacy and safety in the treatment of this chronic inflammatory disease.(https://doi.org/10.5009/gnl17035).